Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The estimated global incidence of acute TBI during 2016 was 27 million cases, and the estimated global prevalence of chronic impairment secondary to TBI was 55.5 million cases.1 Overall, TBI and long-term motor deficits secondary to TBI significantly impair patients’ self-care, employability, and quality of life and are major burdens on health care systems worldwide.
This report presents 6-month prespecified interim data from the 1-year, double-blind, randomized, surgical sham–controlled, phase 2 Stem Cell Therapy for Traumatic Brain Injury (STEMTRA) trial (NCT02416492), in which the intracerebral stereotactic implantation of SB623 cells in patients with chronic motor deficits secondary to TBI appeared to be safe and was associated with a statistically significant improvement of the Fugl-Meyer Motor Scale (FMMS) score over surgical sham–controlled patients.
Learn More: https://n.neurology.org/content/96/8/e1202
