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From Concussion to Alzheimer’s: Mini-Brain Unlocks Time-Sensitive Link


Researchers developed a “traumatic brain injury (TBI) on a chip” to explore the links between concussions and Alzheimer’s disease.

Using clusters of neurons from embryonic mice, they exposed the “miniature brain” to g-forces mimicking those experienced by football players. They found an immediate surge in acrolein, a molecule linked to neurodegenerative diseases, and a significant increase in the misfolding of amyloid-beta 42 (AB42), a protein associated with Alzheimer’s.

The device also served to test potential treatments, such as hydralazine, in reducing acrolein and AB42 levels.

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